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© Emeline Camand
Marquage par immunofluorescence d'astrocytes tumoraux ou astrocytomes (lignée cellulaire humaine U373), montrant en rouge, APC et en vert, la tubuline des microtubules. APC est un supresseur de tumeur qui est impliqué dans la polarisation des astrocytes normaux. La localisation d'APC est altérée dans des lignées de gliomes. Pour essayer de corriger, les dérèglements observés lors de la migration des cellules d'astrocytes tumuraux ou gliomes on cherche à connaitre les mécanismes moléculaires fondamentaux qui controlent la polarisation et la migration cellulaire.
Publication : The Journal of cell biology

P120catenin tuning of VE-cadherin endocytosis controls collective cell behavior during angiogenesis.

Team: Cell Polarity, Migration And Cancer
Member: Sandrine Etienne-Manneville
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of cell biology - 04 May 2020

Etienne-Manneville S,

Link to Pubmed [PMID] – 32339217

Link to DOI – e20200300510.1083/jcb.202003005

J. Cell Biol. 2020 May; 219(5):

How cells can stick together while moving through a complex environment is not fully understood. In this issue, Grimsley-Myers et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.201909081) demonstrate that, in the case of blood vessel formation, the balance between the maintenance of endothelial integrity and the dynamics of cell-cell contacts required for collective migration relies on VE-cadherin endocytosis.