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© Research
Publication : Neuron

Odor discrimination requires proper olfactory fast oscillations in awake mice

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Neuron - 17 Oct 2013

Lepousez G, Lledo PM

Link to Pubmed [PMID] – 24139818

Neuron 2013 Nov;80(4):1010-24

Gamma oscillations are commonly observed in sensory brain structures, notably in the olfactory bulb. The mechanism by which gamma is generated in the awake rodent and its functional significance are still unclear. We combined pharmacological and genetic approaches in the awake mouse olfactory bulb to show that gamma oscillations required the synaptic interplay between excitatory output neurons and inhibitory interneurons. Gamma oscillations were amplified, or abolished, after optogenetic activation or selective lesions to the bulbar output neurons. In response to a moderate increase of the excitation/inhibition ratio in output neurons, long-range gamma synchronization was selectively enhanced while the mean firing activity and the amplitude of inhibitory inputs both remained unchanged in output neurons. This excitation/inhibition imbalance also impaired odor discrimination in an olfactory learning task, suggesting that proper fast neuronal synchronization may be critical for the correct discrimination of similar sensory stimuli.

http://www.ncbi.nlm.nih.gov/pubmed/24139818