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Baseline characteristics and clinical symptoms related to respiratory viruses identified among patients presenting with influenza-like illness in primary care

Tri-mannose grafting of chitosan nanocarriers remodels the macrophage response to bacterial infection

© Research

Publication : Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Nucleic Acids as a Nature-Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues

Team: Archived: Immunobiology of Dendritic Cells

Member: Nikaïa Smith

Scientific Fields

Diseases

Organisms

Applications

Technique

Published in Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 28 Jan 2019

Krüger F, Kumar V, Monge P, Conzelmann C, Smith N, Gothelf KV, Tolstrup M, Münch J, Zelikin AN

Link to Pubmed [PMID] – 30937274

Adv Sci (Weinh) 2019 Mar;6(6):1802095

Macromolecular prodrugs (MP) built on the natural phosphodiester and deoxyribose backbone are developed using marketed antiviral nucleoside analogues. These MP are synthesized using automated synthesis, have defined molecular composition, and have a natural mechanism for drug release. These unique attributes, coupled to the efficient cell entry and potent antiviral effects, position the prodrugs scaffolded on nucleic acids favorably for translational studies.

Published on: 28 Jan 2019