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© Research
Publication : Proceedings of the National Academy of Sciences of the United States of America

Normal serum immunoglobulins participate in the selection of peripheral B-cell repertoires

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Proceedings of the National Academy of Sciences of the United States of America - 01 Jul 1991

Freitas AA, Viale AC, Sundblad A, Heusser C, Coutinho A

Link to Pubmed [PMID] – 1829525

Proc. Natl. Acad. Sci. U.S.A. 1991 Jul;88(13):5640-4

In B-cell development, expression of immunoglobulin heavy-chain variable-region (VH) gene repertoires is determined by genetic mechanisms that favor rearrangement of the most D-proximal genes, resulting in overutilization of the VH7183 gene family early in ontogeny and in differentiating B cells of the adult bone marrow. Maturation of the immune system is accompanied by a decreased expression of VH7183 genes in the peripheral immunocompetent B-cell pool of adult animals. By comparing VH gene family expression in the bone marrow (emergent) and peripheral (available and actual) B-cell repertoires of germ-free and conventionally raised BALB/c mice, we found that peripheral selection of VH gene family utilization does not occur in germ-free animals. Reconstitution of germ-free mice with normal serum immunoglobulins purified from syngeneic donors reestablishes selection of VH7183-expressing B cells. Our results indicate that preimmune B-cell repertoires are selected in normal animals by environmental antigens and serum immunoglobulins.

http://www.ncbi.nlm.nih.gov/pubmed/1829525