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© Research
Publication : Journal of Crohn's & colitis

Nod2 protects the gut from spreading experimental colitis to small intestine

Team: Microenvironment and Immunity
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of Crohn's & colitis - 30 Nov 2019

Al Nabhani Z, Berrebi D, Martinez-Vinson C, Montcuquet N, Madre C, Roy M, Ogier-Denis E, Dussaillant M, Cerf-Bensussan N, Zouali H, Daniel F, Barreau F, Hugot JP

Link to Pubmed [PMID] – 31784737

J Crohns Colitis 2019 Nov;

Nucleotide Oligomerization Domain 2 (NOD2) mutations are key risk factors for Crohn’s disease (CD). NOD2 contributes to intestinal homeostasis by regulating innate and adaptive immunity together with intestinal epithelial function. However, the exact roles of NOD2 in CD and other NOD2-associated disorders remain poorly known.