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© Research
Publication : Science (New York, N.Y.)

Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science (New York, N.Y.) - 06 Jun 2003

Girardin SE, Boneca IG, Carneiro LA, Antignac A, Jéhanno M, Viala J, Tedin K, Taha MK, Labigne A, Zähringer U, Coyle AJ, DiStefano PS, Bertin J, Sansonetti PJ, Philpott DJ

Link to Pubmed [PMID] – 12791997

Science 2003 Jun;300(5625):1584-7

Although the role of Toll-like receptors in extracellular bacterial sensing has been investigated intensively, intracellular detection of bacteria through Nod molecules remains largely uncharacterized. Here, we show that human Nod1 specifically detects a unique diaminopimelate-containing N-acetylglucosamine-N-acetylmuramic acid (GlcNAc-MurNAc) tripeptide motif found in Gram-negative bacterial peptidoglycan, resulting in activation of the transcription factor NF-kappaB pathway. Moreover, we show that in epithelial cells (which represent the first line of defense against invasive pathogens), Nod1is indispensable for intracellular Gram-negative bacterial sensing.

https://www.ncbi.nlm.nih.gov/pubmed/12791997