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Neutrophil myeloperoxidase diminishes the toxic effects and mortality induced by lipopolysaccharide

Fetal Tissues Tested for Microbial Sterility by Culture- and PCR-Based Methods Can be Safely Used in Clinics.

© Research

Publication : Pharmacogenomics

No impact of eight NTRK2 genetic polymorphisms on 6-month antidepressant efficacy in depressed patients

Team: Archived: Experimental neuropathology

Member: Anne-Cecile Petit

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Diseases

Organisms

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Technique

Published in Pharmacogenomics - 17 Feb 2017

Deflesselle E, Verstuyft C, Petit AC, Hardy P, David DJ, Falissard B, Fève B, Rigal L, Becquemont L, Corruble E, Colle R

Link to Pubmed [PMID] – 28244805

Pharmacogenomics 2017 Mar;18(4):349-357

AIM: NTRK2 is the main receptor of the brain derived neurotrophic factor, which is involved in antidepressant efficacy. We assessed the impact of eight NTRK2 SNPs pertaining to response and remission after antidepressant treatment in depressed patients.

PATIENTS & METHODS: In a naturalistic study, 569 patients with a major depressive episode requiring a new antidepressant treatment were genotyped for eight NTRK2 SNPs (rs1187352, rs1439050, rs1778933 rs2289656, rs2289657, rs2289658, rs3824519, rs56142442) and prospectively assessed for response and remission after 6 months of treatment.

RESULTS: No association was shown between the NTRK2 SNPs and response/remission.

CONCLUSION: There is no benefit to assess these eight TRKB SNPs to predict response/remission after antidepressant treatment in depressed patients.

Published on: 17 Feb 2017