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© Research
Publication : Nature neuroscience

NMDA receptor-dependent metaplasticity at hippocampal mossy fiber synapses

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature neuroscience - 01 May 2011

Rebola N, Carta M, Lanore F, Blanchet C, Mulle C

Link to Pubmed [PMID] – 21532578

Nat. Neurosci. 2011 Jun;14(6):691-3

Hippocampal mossy fiber synapses have been reported to lack NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) of AMPA excitatory postsynaptic currents (EPSCs), unlike conventional glutamatergic synapses. An explanation for this difference may reside in the relatively low number of NMDARs at these synapses. Because mossy fiber synapses display LTP selective for NMDARs, we examined whether this would affect the plasticity rules at mossy fiber-CA3 synapses in mouse hippocampal slices. We found that LTP of NMDARs serves as a metaplastic switch making mossy fiber synapses competent for generating NMDAR-dependent LTP of AMPA EPSCs.

http://www.ncbi.nlm.nih.gov/pubmed/21532578