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© Shalin E. Abraham, Michael Häusser, Christoph Schmidt-Hieber, University College London
The dentate gyrus is one of the few mammalian brain regions where new neurons are generated throughout life. The image was taken with a confocal microscope from a parasagittal slice of the mouse hippocampus. Cells were labelled with fluorescent markers: Newly generated neurons are red (doublecortin), mature neurons are green (NeuN), and nuclei are blue (DAPI)
Publication : Cell Reports

NKX2-1 Is Required in the Embryonic Septum for Cholinergic System Development, Learning, and Memory

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cell Reports - 15 Aug 2017

Magno L, Barry C, Schmidt-Hieber C, Theodotou P, Häusser M, Kessaris N

Link to Pubmed [PMID] – 28813670

Cell Rep. 2017 Aug 15;20(7):1572-1584

The transcription factor NKX2-1 is best known for its role in the specification of subsets of cortical, striatal, and pallidal neurons. We demonstrate through genetic fate mapping and intersectional focal septal deletion that NKX2-1 is selectively required in the embryonic septal neuroepithelium for the development of cholinergic septohippocampal projection neurons and large subsets of basal forebrain cholinergic neurons. In the absence of NKX2-1, these neurons fail to develop, causing alterations in hippocampal theta rhythms and severe deficiencies in learning and memory. Our results demonstrate that learning and memory are dependent on NKX2-1 function in the embryonic septum and suggest that cognitive deficiencies that are sometimes associated with pathogenic mutations in NKX2-1 in humans may be a direct consequence of loss of NKX2-1 function.

http://www.sciencedirect.com/science/article/pii/S221112471731032X