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© Institut Pasteur
Cells infected for 24 hrs with C. Trachomatis. The cell nuclei are labelled in blue, the bacteria appear yellow, within the inclusion lumen. A bacterial protein secreted out the inclusion into the host cytoplasm id labelled in red.
Publication : Expert opinion on drug discovery

New directions in antimalarial target validation.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Expert opinion on drug discovery - 01 Feb 2020

Batista FA, Gyau B, Vilacha JF, Bosch SS, Lunev S, Wrenger C, Groves MR,

Link to Pubmed [PMID] – 31959021

Link to DOI – 10.1080/17460441.2020.1691996

Expert Opin Drug Discov 2020 02; 15(2): 189-202

Introduction: Malaria is one of the most prevalent human infections worldwide with over 40% of the world’s population living in malaria-endemic areas. In the absence of an effective vaccine, emergence of drug-resistant strains requires urgent drug development. Current methods applied to drug target validation, a crucial step in drug discovery, possess limitations in malaria. These constraints require the development of techniques capable of simplifying the validation of Plasmodial targets.Areas covered: The authors review the current state of the art in techniques used to validate drug targets in malaria, including our contribution – the protein interference assay (PIA) – as an additional tool in rapid in vivo target validation.Expert opinion: Each technique in this review has advantages and disadvantages, implying that future validation efforts should not focus on a single approach, but integrate multiple approaches. PIA is a significant addition to the current toolset of antimalarial validation. Validation of aspartate metabolism as a druggable pathway provided proof of concept of how oligomeric interfaces can be exploited to control specific activity in vivo. PIA has the potential to be applied not only to other enzymes/pathways of the malaria parasite but could, in principle, be extrapolated to other infectious diseases.

https://pubmed.ncbi.nlm.nih.gov/31959021