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© Research
Publication : Scandinavian journal of immunology

Neonatal tolerance to alloantigens is induced by enriched antigen-presenting cells

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Scandinavian journal of immunology - 01 Aug 1997

Modigliani Y, Burlen-Defranoux O, Bandeira A, Coutinho A

Link to Pubmed [PMID] – 9583991

Scand. J. Immunol. 1997 Aug;46(2):117-21

Spleen and bone marrow cells from normal or Rag-1-deficient donors are equally competent in their ability to induce neonatal transplantation tolerance in semi-allogeneic hosts, and the latter are also capable of tolerizing fully allogeneic recipients. Both types of donor cells resulted in comparable levels of haemopoietic chimerism in tolerant animals. Lymphoid hyperactivity, however, was absent in animals tolerized with Rag-1-deficient cells. The authors conclude that neonatal tolerance induced with haemopoietic cells requires no donor lymphocytes, and is thus not the result of deficient antigen presentation. Furthermore, the state of tolerance can be dissociated from the lymphoid hyperactivity that requires donor lymphocytes and is regularly scored in conventionally tolerized animals.

http://www.ncbi.nlm.nih.gov/pubmed/9583991