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© Research
Publication : European journal of immunology

Naturally activated CD4+ T cells are highly enriched for cytokine-producing cells

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in European journal of immunology - 01 Jun 1998

Cederbom L, Bandeira A, Coutinho A, Ivars F

Link to Pubmed [PMID] – 9645375

Eur. J. Immunol. 1998 Jun;28(6):1934-40

Most T cells in a normal non-immunized individual are in a resting state. However, a small proportion of splenic T cells are large activated cells both in specific pathogen-free and antigen-free mice. To further elucidate the effector functions associated with these “naturally” activated CD4+ T cells, we have characterized the expression of various membrane markers, cytokine production and T helper activity by these cells. We show that naturally activated CD4+ T cells express activation markers and contain tenfold higher proportions of cells producing IL-4, IL-10 and IFN-gamma as compared to small CD4+ T cells. Despite the high proportion of IFN-gamma producers, naturally activated CD4+ T cells still induce B cell proliferation and differentiation. These results are discussed in the context of normal physiological autoreactivity.

http://www.ncbi.nlm.nih.gov/pubmed/9645375