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© Fabrice Chrétien with Ultrapole, colorized by Jean-Marc Panaud
Cellule souche (en jaune) de muscle squelettique partiellement recouverte par la membrane basale, migrant sur une fibre musculaire (en bleu).
Publication : Immunogenetics

Nackt (nkt), a new hair loss mutation of the mouse with associated CD4 deficiency

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Immunogenetics - 01 May 1999

Benavides F, Giordano M, Fiette L, Bueno Brunialti AL, Martin Palenzuela N, Vanzulli S, Baldi P, Schmidt R, Dosne Pasqualini C, Guénet J

Link to Pubmed [PMID] – 10199917

Immunogenetics 1999 May;49(5):413-9

A spontaneous recessive mutation named nackt (symbol: nkt) affecting hair growth and T-cell development was discovered in a moderately inbred stock of mice. Skin lesions were characterized by sparse rough coat, bare patches around the eyes and neck, and a scratching behavior throughout life. Fluorescence-activated cell sorter analysis indicated a deficiency in the CD4(+) 8(-) T-cell subset in the thymus and a marked decrease in CD4(+) T cells in peripheral lymphoid organs. Linkage analysis using a set of molecular markers and an F2 intersubspecific cross indicated that the mutation maps to the central region of mouse chromosome 13, in a region homologous to human chromosome 5q22-q35.

http://www.ncbi.nlm.nih.gov/pubmed/10199917