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© Research
Publication : Briefings in bioinformatics

Multiple sequence alignment modeling: methods and applications

Team: Bioinformatics and Biostatistics HUB
Team: Expertise group : SysBio – System Bioinformatics
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Briefings in bioinformatics - 27 Nov 2015

Chatzou M, Magis C, Chang JM, Kemena C, Bussotti G, Erb I, Notredame C

Link to Pubmed [PMID] – 26615024

Brief. Bioinformatics 2016 11;17(6):1009-1023

This review provides an overview on the development of Multiple sequence alignment (MSA) methods and their main applications. It is focused on progress made over the past decade. The three first sections review recent algorithmic developments for protein, RNA/DNA and genomic alignments. The fourth section deals with benchmarks and explores the relationship between empirical and simulated data, along with the impact on method developments. The last part of the review gives an overview on available MSA local reliability estimators and their dependence on various algorithmic properties of available methods.