Link to Pubmed [PMID] – 12524011
Semin. Cell Dev. Biol. 2003 Feb;14(1):85-92
In female mammals, the majority of the genes on one of the two X-chromosomes are silenced by a process referred to as X-chromosome inactivation. The X-inactivation center (Xic), a complex genomic region on the X-chromosome which controls this process, contains the Xist gene encoding an untranslated RNA which plays a central role in the establishment of the transcriptional repression. The Xic encrypts a sophisticated program which coordinates X inactivation with sex and embryonic development. The present article reviews our current knowledge of the regulatory elements lying within the mouse Xic and of the mechanisms underlying random X inactivation.