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© Research
Publication : Seminars in immunology

Mucosal physical and chemical innate barriers: Lessons from microbial evasion strategies

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Seminars in immunology - 01 May 2015

Sperandio B, Fischer N, Sansonetti PJ

Link to Pubmed [PMID] – 25936225

Semin. Immunol. 2015 Mar;27(2):111-8

The innate immune system has evolved since millions of years under a selective pressure. Among the different host mechanisms selected and conserved as a first line of defense, the gastrointestinal mucus layer constitutes an efficient physical and chemical barrier against invading microbes. Mucin glycoproteins and antimicrobial peptides are the major components of the mucus barrier, and evidences prove that they form an effective protection against most microbes. However, successful pathogens have evolved evasion strategies to circumvent this defense barrier. Here, we discuss the interactions between pathogens, mucins, and antimicrobial peptides, and the mechanisms that pathogens have developed to evade the innate defense systems of the intestinal mucosal barrier.

http://www.ncbi.nlm.nih.gov/pubmed/25936225