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© Research
Publication : Current genetics

Moving forward one step back at a time: reversibility during homologous recombination

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current genetics - 23 May 2019

Piazza A, Heyer WD

Link to Pubmed [PMID] – 31123771

Curr. Genet. 2019 May;

DNA double-strand breaks are genotoxic lesions whose repair can be templated off an intact DNA duplex through the conserved homologous recombination (HR) pathway. Because it mainly consists of a succession of non-covalent associations of molecules, HR is intrinsically reversible. Reversibility serves as an integral property of HR, exploited and tuned at various stages throughout the pathway with anti- and pro-recombinogenic consequences. Here, we focus on the reversibility of displacement loops (D-loops), a central DNA joint molecule intermediate whose dynamics and regulation have recently been physically probed in somatic S. cerevisiae cells. From homology search to repair completion, we discuss putative roles of D-loop reversibility in repair fidelity and outcome.

https://www.ncbi.nlm.nih.gov/pubmed/31123771