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© Research
Publication : International immunology

Most residues on the floor of the antigen binding site of the class I MHC molecule H-2Kd influence peptide presentation

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in International immunology - 01 Aug 1992

Jaulin C, Romero P, Luescher IF, Casanova JL, Prochnicka-Chalufour A, Langlade-Demoyen P, Maryanski JL, Kourilsky P

Link to Pubmed [PMID] – 1358191

Int. Immunol. 1992 Aug;4(8):945-53

A panel of 15 single alanine substitutions on the floor of the peptide binding groove of the murine class I histocompatibility molecule H-2Kd has been analyzed. All but two mutant molecules were expressed on the cell surface, and were tested for peptide binding and presentation to specific cytotoxic T lymphocytes. Eleven out of 13 mutant molecules appeared to be functionally altered. Five of the substituted residues were involved in the presentation of all peptides tested. Three participated in the presentation of certain peptides but not others. Three other residues participated in epitope formation through indirect interactions. Only two mutations had no detectable effect.

http://www.ncbi.nlm.nih.gov/pubmed/1358191