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© Research
Publication : The Journal of infectious diseases

Monkeypox Virus Infection Stimulates a More Robust and Durable Neutralizing Antibody Response Compared to Modified Vaccinia Virus Ankara Vaccination.

Team: Structural biology of infectious diseases
Member: Pablo Guardado-Calvo
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of infectious diseases - 15 Apr 2025

Selverian CN, Monticelli SR, Jaleta YM, Lasso G, DeMouth ME, Meola A, Berrigan J, Batchelor TG, Battini L, Guardado-Calvo P, Herbert AS, Chandran K, Meyerowitz E, Miller EH

Link to Pubmed [PMID] – 39422181

Link to DOI – 10.1093/infdis/jiae515

J Infect Dis 2025 Apr; 231(4): 1069-1073

Monkeypox virus (MPXV) has recently caused a global disease outbreak in humans. Differences in the neutralizing antibody response to vaccination versus MPXV infection remain poorly understood. Here, we examined the neutralization of MPXV and vaccinia virus by sera from a cohort of convalescent and vaccinated individuals at 1 and 8 months postexposure. Convalescent individuals displayed higher neutralizing antibody titers against MPXV than vaccinated and MPXV-naive persons at 1 month postexposure. Neutralizing antibody titers had waned significantly in both groups at 8 months. This study suggests that additional vaccine strategies are needed to elicit a durable humoral response and prevent breakthrough infections.