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© Institut Pasteur
Macrophages et lymphocytes de souris. Image colorisée.
Publication : Science (New York, N.Y.)

Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science (New York, N.Y.) - 01 Aug 2007

Auffray C, Fogg D, Garfa M, Elain G, Join-Lambert O, Kayal S, Sarnacki S, Cumano A, Lauvau G, Geissmann F

Link to Pubmed [PMID] – 17673663

Science 2007 Aug;317(5838):666-70

The cellular immune response to tissue damage and infection requires the recruitment of blood leukocytes. This process is mediated through a classical multistep mechanism, which involves transient rolling on the endothelium and recognition of inflammation followed by extravasation. We have shown, by direct examination of blood monocyte functions in vivo, that a subset of monocytes patrols healthy tissues through long-range crawling on the resting endothelium. This patrolling behavior depended on the integrin LFA-1 and the chemokine receptor CX(3)CR1 and was required for rapid tissue invasion at the site of an infection by this “resident” monocyte population, which initiated an early immune response and differentiated into macrophages.

http://www.ncbi.nlm.nih.gov/pubmed/17673663