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© Research
Publication : Science (New York, N.Y.)

Molecular coupling of Xist regulation and pluripotency

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science (New York, N.Y.) - 19 Sep 2008

Navarro P, Chambers I, Karwacki-Neisius V, Chureau C, Morey C, Rougeulle C, Avner P

Link to Pubmed [PMID] – 18802003

Science 2008 Sep;321(5896):1693-5

During mouse embryogenesis, reversion of imprinted X chromosome inactivation in the pluripotent inner cell mass of the female blastocyst is initiated by the repression of Xist from the paternal X chromosome. Here we report that key factors supporting pluripotency-Nanog, Oct3/4, and Sox2-bind within Xist intron 1 in undifferentiated embryonic stem (ES) cells. Whereas Nanog null ES cells display a reversible and moderate up-regulation of Xist in the absence of any apparent modification of Oct3/4 and Sox2 binding, the drastic release of all three factors from Xist intron 1 triggers rapid ectopic accumulation of Xist RNA. We conclude that the three main genetic factors underlying pluripotency cooperate to repress Xist and thus couple X inactivation reprogramming to the control of pluripotency during embryogenesis.

http://www.ncbi.nlm.nih.gov/pubmed/18802003