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© Research
Publication : Comptes rendus biologies

Messenger RNA in differentiating muscle cells-my experience in François Gros’ lab in the 1970s and 80s.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Comptes rendus biologies - 29 Mar 2024

Buckingham M

Link to Pubmed [PMID] – 38124533

Link to DOI – 10.5802/crbiol.132

C R Biol 2024 Mar; 346(S2): 27-35

I joined François Gros’ laboratory as a postdoc at the end of 1971 and continued working with him as a research scientist until 1987, when I became an independent group leader at the Institut Pasteur. In the early 1970s, it was the beginning of research in his lab on muscle cell differentiation, as a model eukaryotic system for studying mRNAs and gene regulation. In this article, I recount our work on myogenesis and mention the other research themes in his lab and the people concerned. I remained in close contact with François and pay tribute to him as a major figure in French science and as my personal mentor who provided me with constant support.J’ai rejoint le laboratoire de François Gros en tant que postdoctorante à la fin de l’année 1971 et j’ai continué à travailler avec lui en tant que chercheuse jusqu’en 1987, date à laquelle je suis devenue chef de groupe indépendante à l’Institut Pasteur. Au début des années 1970, son laboratoire a commencé à étudier la différenciation des cellules musculaires, comme un système modèle eucaryote permettant d’étudier les ARNm et la régulation des gènes. Dans cet article, je retrace nos travaux sur la myogenèse et mentionne les autres thèmes de recherche de son laboratoire ainsi que les personnes concernées. Je suis restée en contact étroit avec François et je lui rends hommage en tant que figure majeure de la science française et en tant que mentor qui m’a apporté un soutien constant.