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© Research
Publication : Current biology : CB

Mechanism and significance of cis-inhibition in Notch signalling

Team: Dynamics of Developmental Decisions in Drosophila
Member: François Schweisguth
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current biology : CB - 11 Jan 2011

del Álamo D, Rouault H, Schweisguth F

Link to Pubmed [PMID] – 21215938

Curr. Biol. 2011 Jan;21(1):R40-7

Notch receptors in a given cell are activated by cell surface ligands in neighbouring cells but can also be inhibited by the ligands present within the same cell. This process is known as cis-inhibition of Notch. Additionally, reciprocal cis-inhibition of the ligands by Notch has also been observed, albeit to a limited extent. Here, we review the mechanisms, functional relevance and potential implications of these cis-inhibitory interactions for Notch-mediated fate decisions.