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© Michaela Muller-Trutwin
HIV
Publication : Cancer immunology, immunotherapy : CII

MDSCs in infectious diseases: regulation, roles, and readjustment.

Team: HIV, Inflammation and Persistence
Member: Michaela Muller-Trutwin
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cancer immunology, immunotherapy : CII - 01 Apr 2019

Dorhoi A, Glaría E, Garcia-Tellez T, Nieuwenhuizen NE, Zelinskyy G, Favier B, Singh A, Ehrchen J, Gujer C, Münz C, Saraiva M, Sohrabi Y, Sousa AE, Delputte P, Müller-Trutwin M, Valledor AF,

Link to Pubmed [PMID] – 30569204

Link to DOI – 10.1007/s00262-018-2277-y

Cancer Immunol Immunother 2019 Apr; 68(4): 673-685

Many pathogens, ranging from viruses to multicellular parasites, promote expansion of MDSCs, which are myeloid cells that exhibit immunosuppressive features. The roles of MDSCs in infection depend on the class and virulence mechanisms of the pathogen, the stage of the disease, and the pathology associated with the infection. This work compiles evidence supported by functional assays on the roles of different subsets of MDSCs in acute and chronic infections, including pathogen-associated malignancies, and discusses strategies to modulate MDSC dynamics to benefit the host.