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© Research
Publication : Science (New York, N.Y.)

Mating patterns in malaria parasite populations of Papua New Guinea

Team: Archived: Infectious Reservoir of Vector-borne Diseases
Member: Richard Paul
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science (New York, N.Y.) - 22 Sep 1995

Paul RE, Packer MJ, Walmsley M, Lagog M, Ranford-Cartwright LC, Paru R, Day KP

Link to Pubmed [PMID] – 7569897

Science 1995 Sep;269(5231):1709-11

Description of the genetic structure of malaria parasite populations is central to an understanding of the spread of multiple-locus drug and vaccine resistance. The Plasmodium falciparum mating patterns from madang, Papua New Guinea, where intense transmission of malaria occurs, are described here. A high degree of inbreeding occurs in the absence of detectable linkage disequilibrium. This contrasts with other studies, indicating that the genetic structure of malaria parasite populations is neither clonal nor panmictic but will vary according to the transmission characteristics of the region.