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© Perrine Bomme, Guillaume Duménil, Jean-Marc Panaud.
Coloured scanning electron micrograph (SEM) of Neisseria meningitidis on epithelial cells
Publication : Infection

Management of a rifampicin-resistant meningococcal infection in a teenager

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Infection - 14 Feb 2013

Delaune D, Andriamanantena D, Mérens A, Viant E, Aoun O, Ceppa F, Taha MK, Rapp C

Link to Pubmed [PMID] – 23408002

Infection 2013 Jun;41(3):705-8

We report a secondary case of rifampicin-resistant meningococcal disease and our experience in managing contact cases. Rifampicin resistance resulting from rpoB gene mutations is still uncommon enough that changing the current recommendations for chemoprophylaxis is unwarranted. However, ensuring limited but appropriate chemoprophylaxis may prevent the development of antimicrobial resistance. Thus, the definition of contact cases should be strictly respected. In the case of culture-positive Neisseria meningitidis, in vitro susceptibility testing to rifampicin must be systematically performed in order to detect rifampicin-resistant strains and, thus, institute appropriate prophylaxis in order to prevent secondary transmission.

https://www.ncbi.nlm.nih.gov/pubmed/23408002