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© Pierre Lafaye
Astrocytes marqués par des anticorps VHH anti-GFAP. Des anticorps d'alpagas dirigés contre une protéine spécifique des astrocytes, la GFAP (Glial Fibrillary Acidic Protein), ont été obtenus à partir de camélidés immunisés. La partie VHH (partie de l'anticorps qui reconnaît l'antigène) a été exprimée sous forme recombinante chez Escherichia coli.
Publication : FEBS letters

Location of penicilloyl groups on CNBr fragments of the albumin from penicillin-treated patients

Team: Antibody Engineering
Member: Pierre Lafaye
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in FEBS letters - 10 Aug 1987

Lafaye P, Lapresle C

Link to Pubmed [PMID] – 3609313

FEBS Lett. 1987 Aug;220(1):206-8

Two fixation sites for penicilloyl groups on human albumin were demonstrated. Using CNBr cleavage the first site was located between methionine 123 and methionine 297 and the second one between methionine 297 and the C-terminal residue. In both cases, penicilloyl groups were unmasked by pronase degradation or disulfide bond reduction.