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© A-M. Pais-Correia, M-I. Thoulouze, A. Alcover, A. Gessain
Mise en évidence de structures de type "biofilm ", formées par le rétrovirus HTLV-1 générés par des cellules infectées (cellules du haut), qui ont été transmis à un autre lymphocyte (cellule du bas). Micrographie en microscopie électronique à balayage. Image colorisée.
Publication : Retrovirology

Localization, quantification and interaction with host factors of endogenous HTLV-1 HBZ protein in infected cells and ATL

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Retrovirology - 04 Jul 2015

Raval GU, Bidoia C, Forlani G, Tosi G, Gessain A, Accolla RS

Link to Pubmed [PMID] – 26140924

Retrovirology 2015;12(1):59

Human T cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of a severe form of neoplasia designated Adult T cell Leukaemia (ATL). It is widely accepted that the viral transactivator Tax-1 is the major viral product involved in the onset, but not in the maintenance, of neoplastic phenotype, as only 30-40% of ATL cells express Tax-1. It has been recently demonstrated that HBZ (HTLV-1 bZIP factor), a protein encoded by the minus strand of HTLV-1 genome, constantly expressed in infected cells and in ATL tumor cells, is also involved in the pathogenesis of leukaemia. The full role played by HBZ in oncogenesis is not clarified in detail also because of the limited availability of tools to assess quantitative expression, subcellular location and interaction of HBZ with host factors in ATL.

http://www.ncbi.nlm.nih.gov/pubmed/26140924