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© Research
Publication : Epigenetics & chromatin

Leo1 is essential for the dynamic regulation of heterochromatin and gene expression during cellular quiescence

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Epigenetics & chromatin - 17 Jul 2019

Oya E, Durand-Dubief M, Cohen A, Maksimov V, Schurra C, Nakayama JI, Weisman R, Arcangioli B, Ekwall K

Link to Pubmed [PMID] – 31315658

Epigenetics Chromatin 2019 07;12(1):45

Cellular quiescence is a reversible differentiation state during which cells modify their gene expression program to inhibit metabolic functions and adapt to a new cellular environment. The epigenetic changes accompanying these alterations are not well understood. We used fission yeast cells as a model to study the regulation of quiescence. When these cells are starved for nitrogen, the cell cycle is arrested in G1, and the cells enter quiescence (G0). A gene regulatory program is initiated, including downregulation of thousands of genes-for example, those related to cell proliferation-and upregulation of specific genes-for example, autophagy genes-needed to adapt to the physiological challenge. These changes in gene expression are accompanied by a marked alteration of nuclear organization and chromatin structure.

https://www.ncbi.nlm.nih.gov/pubmed/31315658