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© Research
Publication : Expert opinion on pharmacotherapy

Leflunomide for the treatment of rheumatoid arthritis

Member: Clementine Schilte
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Expert opinion on pharmacotherapy - 01 Jun 2003

Miceli-Richard C, Dougados M

Link to Pubmed [PMID] – 12783594

Expert Opin Pharmacother 2003 Jun;4(6):987-97

Leflunomide (Arava), Aventis Pharmaceuticals) is an immunomodulating drug that interferes with the metabolism of pyrimidine by inhibiting dihydro-orotate dehydrogenase (DHO-DH) in mitochondria, thereby blocking T- and B cell proliferation. Antibody production is also affected by DHO-DH blockade. Other immunomodulatory effects of leflunomide have also been reported. Symptomatic and structural effects of leflunomide in active rheumatoid arthritis have been strictly evaluated by double-blind, randomised, placebo-controlled studies that were aimed at validating its use in rheumatoid arthritis. Further trials are now required to confirm efficacy and safety of this drug in combination with other agents.