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© Research
Publication : Expert opinion on pharmacotherapy

Leflunomide for the treatment of rheumatoid arthritis

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Expert opinion on pharmacotherapy - 01 Jun 2003

Miceli-Richard C, Dougados M

Link to Pubmed [PMID] – 12783594

Expert Opin Pharmacother 2003 Jun;4(6):987-97

Leflunomide (Arava), Aventis Pharmaceuticals) is an immunomodulating drug that interferes with the metabolism of pyrimidine by inhibiting dihydro-orotate dehydrogenase (DHO-DH) in mitochondria, thereby blocking T- and B cell proliferation. Antibody production is also affected by DHO-DH blockade. Other immunomodulatory effects of leflunomide have also been reported. Symptomatic and structural effects of leflunomide in active rheumatoid arthritis have been strictly evaluated by double-blind, randomised, placebo-controlled studies that were aimed at validating its use in rheumatoid arthritis. Further trials are now required to confirm efficacy and safety of this drug in combination with other agents.

https://www.ncbi.nlm.nih.gov/pubmed/12783594