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© Research
Publication : Scientific reports

Layer-specific potentiation of network GABAergic inhibition in the CA1 area of the hippocampus.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Scientific reports - 27 Jun 2016

Colavita M, Terral G, Lemercier CE, Drago F, Marsicano G, Massa F,

Link to Pubmed [PMID] – 27345695

Link to DOI – 2845410.1038/srep28454

Sci Rep 2016 Jun; 6(): 28454

One of the most important functions of GABAergic inhibition in cortical regions is the tight control of spatiotemporal activity of principal neuronal ensembles. However, electrophysiological recordings do not provide sufficient spatial information to determine the spatiotemporal properties of inhibitory plasticity. Using Voltage Sensitive Dye Imaging (VSDI) in mouse hippocampal slices, we demonstrate that GABAA-mediated field inhibitory postsynaptic potentials undergo layer-specific potentiation upon activation of metabotropic glutamate receptors (mGlu). VSDI recordings allowed detection of pharmacologically isolated GABAA-dependent hyperpolarization signals. Bath-application of the selective group-I mGlu receptor agonist, (S)-3,5-Dihydroxyphenylglycine (DHPG), induces an enhancement of the GABAergic VSDI-recorded signal, which is more or less pronounced in different hippocampal layers. This potentiation is mediated by mGlu5 and downstream activation of IP3 receptors. Our results depict network GABAergic activity in the hippocampal CA1 region and its sub-layers, showing also a novel form of inhibitory synaptic plasticity tightly coupled to glutamatergic activity.

https://pubmed.ncbi.nlm.nih.gov/27345695