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© Research
Publication : Genes & development

Large scale transgenic and cluster deletion analysis of the HoxD complex separate an ancestral regulatory module from evolutionary innovations

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Genes & development - 01 Sep 2001

Spitz F, Gonzalez F, Peichel C, Vogt TF, Duboule D, Zákány J

Link to Pubmed [PMID] – 11544178

Genes Dev. 2001 Sep;15(17):2209-14

The ancestral role of the Hox gene family is specifying morphogenetic differences along the main body axis. In vertebrates, HoxD genes were also co-opted along with the emergence of novel structures such as limbs and genitalia. We propose that these functional recruitments relied on the appearance, or implementation, of regulatory sequences outside of the complex. Whereas transgenic human and murine HOXD clusters could function during axial patterning, in mice they were not expressed outside the trunk. Accordingly, deletion of the entire cluster abolished axial expression, whereas recently acquired regulatory controls were preserved.