Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search

← Go to Research

Go back
Scroll to top
Share
© Jean Marc Panaud
Cyanobactérie souche "PCC 9401". Souche de la "Pasteur Culture Collection of Cyanobacteria" conservée à l'état axénique dans l'Unité des Cyanobactéries. La PCC est l'une des Collections spécialisées de l'Institut Pasteur.
Publication : Angewandte Chemie (International ed. in English)

Landornamides, antiviral ornithine-containing ribosomal peptides discovered by proteusin mining

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Angewandte Chemie (International ed. in English) - 13 Jul 2020

Bösch N, Mariana B, Greczmiel U, Morinaka B, Gugger M, Oxenius A, Vagstad AL, Piel J

Link to Pubmed [PMID] – 32163654

Link to DOI – 10.1002/anie.201916321

Angew. Chem. Int. Ed. Engl. 2020 Jul 13;59(29):11763-11768

Les proteusines sont une famille de peptides ribosomiques bactériens qui restent largement élargis des métabolites hypothétiques prédits par le génome. Les seuls membres connus sont les cytotoxines de type polythéonamide avec des structures remarquablement complexes en raison de nombreuses modifications post-traductionnelles habituelles (PTM). Les cyanobactéries contiennent un grand nombre de loci de proteusine putatifs avec des ensembles très variables de gènes candidats PTM. En demandant si cette diversité génétique offre un potentiel de découverte chimique et pharmacologique au-delà des composés de type polythéonamide, nous avons caractérisé le landornamide A, le produit du cluster de gènes osp silencieux de Kamptonema sp.PCC 6506. La reconstruction de la voie dans E. coli a révélé un peptide combinant des lanthionines, des résidus d et, en tant que nouveau PTM, deux ornithines introduites par l’enzyme de type arginase OspR. Le Landornamide A a inhibé le virus de la chorioméningite lymphocytaire infectant les cellules du fibrosarcome de souris, représentant l’un des rares composés anti-arénaviraux connus. Les données soutiennent les proteusines en tant que ressource riche d’échafaudages chimiques, de nouvelles enzymes de maturation et de bioactivités.