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© Research
Publication : The EMBO journal

Kidney and submaxillary gland renins are encoded by two non-allelic genes in Swiss mice

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The EMBO journal - 01 Jan 1983

Panthier JJ, Rougeon F

Link to Pubmed [PMID] – 6357783

EMBO J. 1983;2(5):675-8

Two distinct phenotypic groups of inbred strains of mice, with different amounts of submaxillary gland (SMG) renin have been described. We have previously shown that strains with high levels of SMG renin, such as Swiss or AKR mice, have two renin genes, Rn1 and Rn2, per haploid genome, while strains with low levels of SMG, such as BALB/c or C57Bl/6, have only one renin gene. We now report the molecular cloning of cDNA copies of Swiss mouse kidney renin mRNA and present nucleotide sequence data of the recombinant clones. Comparison of these sequences with the sequence of Swiss mouse SMG renin mRNA we have previously reported, demonstrates that Swiss mice express the two non-allelic genes, Rn1 and Rn2.

http://www.ncbi.nlm.nih.gov/pubmed/6357783