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© Research
Publication : Cell

Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis

Member: Ana Cumano
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cell - 01 May 1998

Neubauer H, Cumano A, Müller M, Wu H, Huffstadt U, Pfeffer K

Link to Pubmed [PMID] – 9590174

Cell 1998 May;93(3):397-409

Janus kinases (Jaks) play an important role in signal transduction via cytokine and growth factor receptors. A targeted inactivation of Jak2 was performed. Jak2-/- embryos are anemic and die around day 12.5 postcoitum. Primitive erythrocytes are found, but definitive erythropoiesis is absent. Compared to erythropoietin receptor-deficient mice, the phenotype of Jak2 deficiency is more severe. Fetal liver BFU-E and CFU-E colonies are completely absent. However, multilineage hematopoietic stem cells (CD34low, c-kit(pos)) can be found, and B lymphopoiesis appears intact. In contrast to IFNalpha stimulation, Jak2-/- cells do not respond to IFNgamma. Jak2-/- embryonic stem cells are competent for LIF signaling. The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis.