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© Research
Publication : Antimicrobial agents and chemotherapy

ISAba1-mediated blaADC disruption restores third-generation cephalosporin susceptibility in a clinical Acinetobacter baumannii isolate.

Member: Carolina Nodari
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Antimicrobial agents and chemotherapy - 18 Nov 2025

Nodari CS, Bai Q, Cayô R, Streling AP, Alberto-Lei F, Wille J, C Pignatari AC, Seifert H, Gales AC, Higgins PG

Link to Pubmed [PMID] – 41251368

Link to DOI – 10.1128/aac.00707-25

Antimicrob Agents Chemother 2025 Nov; (): e0070725

This study describes the effects of the insertion of ISAba1 in the intrinsic blaADC gene of an Acinetobacter baumannii isolate showing co-resistance to carbapenems and colistin. Isolate 52971 showed low ceftazidime MIC values due to the disruption of blaADC-195 by this insertion sequence. The introduction of an intact blaADC in isolate 52971 increased ceftazidime MIC. The potential of insertion sequences to inactivate chromosome-encoded resistance determinants should be explored.