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© Research
Publication : PloS one

Is the discopathy associated with Modic changes an infectious process? Results from a prospective monocenter study.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PloS one - 01 Jan 2019

Ahmed-Yahia S, Decousser JW, Flouzat-Lachaniette CH, Dervin G, Roubineau F, Audureau E, Hourdille A, Royer G, Eymard F, Chevalier X,

Link to Pubmed [PMID] – 31415619

Link to DOI – 10.1371/journal.pone.0221030

PLoS One 2019 ; 14(8): e0221030

The local infectious origin and the putative role of Cutibacterium acnes (CA) of a particular subtype of discopathy (Modic 1) are still debated.To establish the association of CA in intervertebral disc (IVD) and Modic 1 discopathy in patients with low back pain.The prevalence of bacteria in IVD samples obtained by anterior approach in patient with chronic low back pain harboring Modic type 1, 2 or no Modic changes was compared to that measured in IVD samples obtained by posterior approach for sciatica. From 45 patients included in the study, 77 discs samples were obtained: 58 by anterior approach (32 Modic 1/2 changes, 26 without Modic change) and 19 by posterior approach. Conventional microbial cultures, universal 16S rRNA molecular detection and a CA specific PCR were performed.12 /77 (15.6%) disc samples were culture positive. Among the 10 CA positive cultures, 5 out of 58 (8.6%) were identified from specimens obtained by anterior approach and 5/19 (26.3%) from posterior approach (p = 0.046). Moreover, the percentage of CA culture positive sample was statistically no different between the patient with or without Modic changes. The CA prevalence was lower through molecular, culture-free approaches: the universal 16S rRNA PCR was positive for 6 specimens, including one CA positive sample and the CA specific PCR was positive for one specimen obtained by posterior approach.In spine surgery the prevalence of CA in culture was significantly higher in IVD samples collected through a posterior approach compared to an anterior approach, suggesting a contamination process. This study did not support the CA related local infectious origin of Modic 1 discopathy.

https://pubmed.ncbi.nlm.nih.gov/31415619