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Microbiology. TB–a new target, a new drug

Comparative genomics of hemiascomycete yeasts: genes involved in DNA replication, repair, and recombination

© Research

Publication : Human reproduction (Oxford, England)

Is the CAG repeat of mitochondrial DNA polymerase gamma (POLG) associated with male infertility? A multi-centre French study

Team: Human Developmental Genetics

Member: Kenneth McElreavey

Scientific Fields

Diseases

Organisms

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Technique

Published in Human reproduction (Oxford, England) - 13 Jan 2005

Aknin-Seifer IE, Touraine RL, Lejeune H, Jimenez C, Chouteau J, Siffroi JP, McElreavey K, Bienvenu T, Patrat C, Levy R

Link to Pubmed [PMID] – 15650046

Hum. Reprod. 2005 Mar;20(3):736-40

Recent data emphasized the implication of polymerase gamma (POLG) CAG repeats in infertility, making it a very attractive gene for study. A comparison of POLG CAG repeats in infertile and fertile men showed a clear association between the absence of the usual 10-CAG allele and male infertility, excluding azoospermia. It has also been suggested that the POLG gene polymorphism should be considered as a possible contributing factor in unexplained couple infertility where semen parameters are normal. In this study, we investigated the POLG CAG repeats, in a well-defined population of patients with severe male factor infertility.

Published on: 13 Jan 2005