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© A. Alanio, E. Perret
Prolifération de Cryptococcus neoformans dans des macrophages murins.
Publication : Antimicrobial agents and chemotherapy

Is It Time for Systematic Voriconazole Pharmacogenomic Investigation for Central Nervous System Aspergillosis?

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Antimicrobial agents and chemotherapy - 27 Aug 2018

Danion F, Jullien V, Rouzaud C, Abdel Fattah M, Lapusan S, Guéry R, Bigé N, Morgand M, Pallet N, Lanternier F, Lortholary O

Link to Pubmed [PMID] – 29967027

Antimicrob. Agents Chemother. 2018 09;62(9)

Voriconazole is the standard treatment for invasive aspergillosis but requires therapeutic drug monitoring to optimize therapy. We report two cases of central nervous system aspergillosis treated with voriconazole. Because of low trough plasma concentrations, we identified gain-of-function mutations in CYP2C19 that were partially responsible for the therapeutic failure of voriconazole. We suggest that systematic voriconazole pharmacogenomic investigation of cerebral aspergillosis be performed to avoid effective therapy delay in this life-threatening disease.

https://www.ncbi.nlm.nih.gov/pubmed/29967027