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© Research
Publication : Proceedings of the National Academy of Sciences of the United States of America

Ionic contrast terahertz near-field imaging of axonal water fluxes

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Proceedings of the National Academy of Sciences of the United States of America - 17 Mar 2006

Masson JB, Sauviat MP, Martin JL, Gallot G

Link to Pubmed [PMID] – 16547134

Proc. Natl. Acad. Sci. U.S.A. 2006 Mar;103(13):4808-12

We demonstrate the direct and noninvasive imaging of functional neurons by ionic contrast terahertz near-field microscopy. This technique provides quantitative measurements of ionic concentrations in both the intracellular and extracellular compartments and opens the way to direct noninvasive imaging of neurons during electrical, toxin, or thermal stresses. Furthermore, neuronal activity results from both a precise control of transient variations in ionic conductances and a much less studied water exchange between the extracellular matrix and the intraaxonal compartment. The developed ionic contrast terahertz microscopy technique associated with a full three-dimensional simulation of the axon-aperture near-field system allows a precise measurement of the axon geometry and therefore the direct visualization of neuron swelling induced by temperature change or neurotoxin poisoning. Water influx as small as 20 fl per mum of axonal length can be measured. This technique should then provide grounds for the development of advanced functional neuroimaging methods based on diffusion anisotropy of water molecules.

http://www.ncbi.nlm.nih.gov/pubmed/16547134