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  • Clinician Researcher
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  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
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© Research
Publication : Biopreservation and biobanking

Intraindividual Temporal miRNA Variability in Serum, Plasma, and White Blood Cell Subpopulations.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Biopreservation and biobanking - 01 Oct 2016

Ammerlaan W, Betsou F,

Link to Pubmed [PMID] – 27096687

Biopreserv Biobank 2016 Oct; 14(5): 390-397

Blood microRNAs (miRNAs) are ideal biomarkers, and blood derivatives are often collected in the scope of miRNA research projects. However, knowledge of temporal variations of miRNAs in healthy individuals is lacking. In this study, miRNA variability was measured over a 1-year period in different blood derivatives, collected every 2-3 months from two healthy donors. There is a continuum of intraindividual temporal variability, with particularly stable (coefficient of variation [CV] 100%-130%) miRNAs in serum, plasma, and specific white blood cell subpopulations. The temporal intraindividual variability of miRNAs should be taken into consideration in experimental design of biospecimen collections and validation of diagnostic biomarkers.

https://pubmed.ncbi.nlm.nih.gov/27096687