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© Research
Publication : Science (New York, N.Y.)

Interaction between PRP11 and SPP91 yeast splicing factors and characterization of a PRP9-PRP11-SPP91 complex

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science (New York, N.Y.) - 01 Oct 1993

Legrain P, Chapon C

Link to Pubmed [PMID] – 8211114

Science 1993 Oct;262(5130):108-10

Several proteins are involved in the early steps of the spliceosome assembly pathway. Protein-protein interactions have been identified between two Saccharomyces cerevisiae yeast splicing factors, PRP9 and SPP91. Here it is demonstrated that protein-protein interactions occur between SPP91 and PRP11. The combination of the prp9-1 mutant and a truncated prp11 mutant exhibits a synthetic lethal phenotype, suggestive of a common biochemical defect. The PRP9 and PRP11 proteins do not interact directly, but the PRP9 and PRP11 molecules can simultaneously bind SPP91 to form a three-molecule complex. Structurally and functionally related proteins are found in mammalian cells and are associated in a single biochemical fraction. This strongly suggests that the PRP9-SPP91-PRP11 complex is a key element of the splicing machinery.

https://www.ncbi.nlm.nih.gov/pubmed/8211114