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© Research
Publication : Microbes and infection

Insights into Streptococcus agalactiae PI-2b pilus biosynthesis and role in adherence to host cells

Team: Group: Shaynoor Dramsi
Member: Shaynoor Dramsi
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Microbes and infection - 10 Nov 2018

Périchon B, Guignot J, Szili N, Gao C, Poyart C, Trieu-Cuot P, Dramsi S

Link to Pubmed [PMID] – 30419351

Microbes Infect. 2019 03;21(2):99-103

The core PI-2b pilus present in “hypervirulent” ST-17 Streptococcus agalactiae strains consists of three pilin subunits (Spb1, Ap1 and Ap2) assembled by sortase SrtC1 and cell-wall anchored by Srt2. Spb1 was shown to be the major pilin and Ap2 the anchor pilin. Ap1 is a putative adhesin. Two additional genes, orf and lep, are part of this operon. The contribution of Lep and Ap1 to the biogenesis of the PI-2b pilus was investigated. Concerning the role of PI-2b, we found that higher PI-2b expression resulted in higher adherence to human brain endothelial cells and higher phagocytosis by human THP1 macrophages.