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© Research
Publication : Journal of virology

Insights into a viral lytic pathway from an archaeal virus-host system

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of virology - 05 Dec 2012

Snyder JC, Brumfield SK, Kerchner KM, Quax TE, Prangishvili D, Young MJ

Link to Pubmed [PMID] – 23221563

J. Virol. 2013 Feb;87(4):2186-92

Archaeal host cells infected by Sulfolobus turreted icosahedral virus (STIV) and Sulfolobus islandicus rod-shaped virus 2 (SIRV2) produce unusual pyramid-like structures on the cell surface prior to virus-induced cell lysis. This viral lysis process is distinct from known viral lysis processes associated with bacterial or eukaryal viruses. The STIV protein C92 and the SIRV2 protein 98 are the only viral proteins required for the formation of the pyramid lysis structures of STIV and SIRV2, respectively. Since SIRV2 and STIV have fundamentally different morphotypes and genome sequences, it is surprising that they share this lysis system. In this study, we have constructed a collection of C92/P98 chimeric proteins and tested their abilities, both in the context of virus replication and alone, to form pyramid lysis structures in S. solfataricus. The results of this study illustrate that these proteins are functionally homologous when expressed as individual chimeric proteins but not when expressed in the context of complete STIV infection.

http://www.ncbi.nlm.nih.gov/pubmed/23221563