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© Fabrice Chrétien with Ultrapole, colorized by Jean-Marc Panaud
Cellule souche (en jaune) de muscle squelettique partiellement recouverte par la membrane basale, migrant sur une fibre musculaire (en bleu).
Publication : Annals of intensive care

Insights and limits of translational research in critical care medicine

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Annals of intensive care - 30 Apr 2015

Pène F, Ait-Oufella H, Taccone FS, Monneret G, Sharshar T, Tamion F, Mira JP,

Link to Pubmed [PMID] – 25977834

Ann Intensive Care 2015;5:8

Experimental research has always been the cornerstone of pathophysiological and therapeutic advances in critical care medicine, where clinical observations and basic research mutually fed each other in a so-called translational approach. The objective of this review is to address the different aspects of translational research in the field of critical care medicine. We herein highlighted some demonstrative examples including the animal-to-human approach to study host-pathogen interactions, the human-to-animal approach for sepsis-induced immunosuppression, the still restrictive human approach to study critical illness-related neuromyopathy, and the technological developments to assess the microcirculatory changes in critically ill patients. These examples not only emphasize how translational research resulted in major improvements in the comprehension of the pathophysiology of severe clinical conditions and offered promising perspectives in critical care medicine but also point out the obstacles to translate such achievements into clinical practice.

http://www.ncbi.nlm.nih.gov/pubmed/25977834