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© Artur Scherf
Scanning Electron Microscopy of Red Blood Cell infected by Plasmodium falciparum.
Publication : Journal of clinical microbiology

Individual Plasmodium vivax msp1 variants within polyclonal P. vivax infections display different propensities for relapse

Team: Biology of Host-parasite Interactions
Member: Didier Ménard
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of clinical microbiology - 11 Jan 2012

Lin JT, Juliano JJ, Kharabora O, Sem R, Lin FC, Muth S, Ménard D, Wongsrichanalai C, Rogers WO, Meshnick SR

Link to Pubmed [PMID] – 22205791

J. Clin. Microbiol. 2012 Apr;50(4):1449-51

Using a newly developed Plasmodium vivax merozoite surface protein 1 gene (Pvmsp1) heteroduplex tracking assay, we genotyped 107 P. vivax infections in individuals from Cambodia, 45 of whom developed recurrent parasitemia within 42 days. The majority of isolates were polyclonal, but recurrent parasitemias displayed fewer variants compared to initial parasitemias. Two Pvmsp1 gene variants occurred more frequently in the initial genotypes of those who developed recurrent parasitemia, representing the first time P. vivax variants associated with a higher risk of relapse have been described.