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© Research
Publication : PloS one

Individual Correlates of Infectivity of Influenza A Virus Infections in Households

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PloS one - 06 May 2016

Tsang TK, Fang VJ, Chan KH, Ip DK, Leung GM, Peiris JS, Cowling BJ, Cauchemez S

Link to Pubmed [PMID] – 27153194

PLoS ONE 2016;11(5):e0154418

BACKGROUND: Identifying individual correlates of infectivity of influenza virus is important for disease control and prevention. Viral shedding is used as a proxy measure of infectivity in many studies. However, the evidence for this is limited.

METHODS: In a detailed study of influenza virus transmission within households in 2008-12, we recruited index cases with confirmed influenza infection from outpatient clinics, and followed up their household contacts for 7-10 days to identify secondary infections. We used individual-based hazard models to characterize the relationship between individual viral shedding and individual infectivity.

RESULTS: We analyzed 386 households with 1147 household contacts. Index cases were separated into 3 groups according to their estimated level of viral shedding at symptom onset. We did not find a statistically significant association of virus shedding with transmission. Index cases in medium and higher viral shedding groups were estimated to have 21% (95% CI: -29%, 113%) and 44% (CI: -16%, 167%) higher infectivity, compared with those in the lower viral shedding group.

CONCLUSIONS: Individual viral load measured by RT-PCR in the nose and throat was at most weakly correlated with individual infectivity in households. Other correlates of infectivity should be examined in future studies.

https://www.ncbi.nlm.nih.gov/pubmed/27153194