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© Research
Publication : Biologicals : journal of the International Association of Biological Standardization

Inactivated rabies vaccine control and release: use of an ELISA method

Team: Archived: Antiviral Strategies
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Biologicals : journal of the International Association of Biological Standardization - 01 Mar 2003

Fournier-Caruana J, Poirier B, Haond G, Jallet C, Fuchs F, Tordo N, Perrin P

Link to Pubmed [PMID] – 12623055

Biologicals 2003 Mar;31(1):9-16

Quality control of human rabies vaccines performed by National Control Laboratories (NCLs) prior to marketing vaccines batches requires in vivo and in vitro potency assays as requested by the relevant European Pharmacopoeia monographs, OMCLs guidelines and WHO technical recommendations. The aim of the present study was to check the suitability of an enzyme-linked immunosorbent assay (ELISA) using a virus neutralizing monoclonal antibody, directed to the rabies virus glycoprotein, to monitor the consistency of the lot to lot rabies vaccines production. Furthermore, this work was implemented to establish in house specifications for the glycoprotein content.