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Sequential calcium binding to the regulatory domain of calcium vector protein reveals functional asymmetry and a novel mode of structural rearrangement

Comparative genomics uncovers large tandem chromosomal duplications in Mycobacterium bovis BCG Pasteur

© Research

Publication : The Journal of antimicrobial chemotherapy

In vitro potency of moxifloxacin, clinafloxacin and sitafloxacin against 248 genetically defined clinical isolates of Staphylococcus aureus

Team: Microbial Evolutionary Genomics

Member: Sylvain Brisse

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Diseases

Organisms

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Technique

Published in The Journal of antimicrobial chemotherapy - 01 Jul 2000

Schmitz FJ, Fluit AC, Milatovic D, Verhoef J, Heinz HP, Brisse S

Link to Pubmed [PMID] – 10882698

J. Antimicrob. Chemother. 2000 Jul;46(1):109-13

The in vitro potency of three newer fluoroquinolones, moxifloxacin, clinafloxacin and sitafloxacin was tested against 248 genetically defined Staphylococcus aureus isolates, comprising 116 unrelated S. aureus, seven heterogeneous intermediate vancomycin-resistant S. aureus strains as well as 125 clonally related methicillin-resistant S. aureus. All strains were susceptible to clinafloxacin and sitafloxacin based on an investigational breakpoint of 1 mg/L and were less influenced by mutations within the grl and gyr gene loci. In one-quarter to one-third of the strains tested, reserpine decreased slightly the MICs of moxifloxacin, clinafloxacin and sitafloxacin. Compared with moxifloxacin, clinafloxacin and sitafloxacin showed a significantly increased anti-staphylococcal potency.

Published on: 01 Jul 2000