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© Charles Dauguet
Virus VIH-1 (HIV-1), agent du sida, à la surface d'un lymphocyte. Image colorisée.
Publication : Cellular immunology

In vitro and in vivo immunosuppressive effects of supernatants from human choriocarcinoma cell lines

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cellular immunology - 01 Dec 1991

Krishnan L, Menu E, Chaouat G, Talwar GP, Raghupathy R

Link to Pubmed [PMID] – 1834345

Cell. Immunol. 1991 Dec;138(2):313-25

Local immunosuppression mediated by placental suppressor factors may contribute to the absence of consistently demonstrable cellular immunity against the fetus. In this context, we have investigated the immunosuppressive capabilities of supernatants from human trophoblastic choriocarcinoma cell lines (HCS) by testing the effects of HCS on immune responses in vitro and in vivo in the human and murine systems. HCS suppresses mitogen-induced proliferation and mixed lymphocyte reactions in humans and in mice, as well as antigen-induced T cell proliferation in mice. HCS also suppresses the in vivo response of mice to allogeneic cells. Furthermore, HCS when injected intraperitoneally causes the induction of suppressor cells in mice which in turn prevent the mounting of an allogeneic response in other strains of mice. These results indicate that human choriocarcinoma cell lines secrete a suppressor factor(s) which induces suppression in vitro as well as in vivo through the generation of suppressor cells.

http://www.ncbi.nlm.nih.gov/pubmed/1834345